HSNIK
[Encoded by MAP3K14 Gene (MAP3K Family) and expressed in small intestine, spleen, thymus, peripheral leukocytes, testis, prostate, ovary, and colon, autophosphorylated 947-amino acid 104-kD cytoplasmic Ser/Thr Protein Kinase NIK is involved in NFKB activation. NIK selectively activates NFKB cascades of TNF/NGF receptors and IL1R type-I. TNFA acts through TRAF2; IL1 acts through IRAK1 and TRAF6. LTBR and CD95 also act through NIK. NIK appears to bind TRAFs 2, 5, and 6, IKKA, and NFKB2/p100. Binding to TRAF2 involves the TRAF2 N- and C-terminal regions. NIK induces NFKB2/p100 processing, degradation of phosphoserine-induced ubiquitinated destruction of IKBA, and release of cytoplasmic NFKB for nuclear translocation and kappa-B DNA-mediated gene expression. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1335946MAP3K14
MAP3K14 Protein
Mitogen-Activated Protein Kinase Kinase Kinase 14
NFKB-Inducing Kinase
NIK
Serine/Threonine Protein Kinase NIK
MAP3K14 Protein
Mitogen-Activated Protein Kinase Kinase Kinase 14
NFKB-Inducing Kinase
NIK
Serine/Threonine Protein Kinase NIK
- Amino Acid, Peptide, or Protein
- Enzyme
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