HYDROXYZINE

[A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic. ( NCI )]

UMLS (NCI) C0020404

Organic Chemical
Pharmacologic Substance

Relation/PAR: Piperazines
[AH500] ANTIHISTAMINES, PIPERAZINE

Relation/CHD: CETIRIZINE
1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine Hydrochloride
2-Naphthoic Acid, 4,4'-methylenebis(3-hydroxy-, ester with 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)-ethoxy)ethanol
1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine Hydrochloride
2-Naphthoic Acid, 4,4'-methylenebis(3-hydroxy-, ester with 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)-ethoxy)ethanol

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