IAP Family Protein

[Encoded by Mammalian IAP Family Genes, conserved (Inhibitors of Apoptosis) IAP Family Proteins exhibit an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI) ( NCI )]

UMLS (NCI) C0893445

IAP Protein
Inhibitor of Apoptosis Protein

Amino Acid, Peptide, or Protein
Biologically Active Substance

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