IMP Dehydrogenase 1

[Expressed as 2 alternative isoforms by human IMPDH1 Gene (IMPDH/GMPR Family), conserved homotetrameric IMP Dehydrogenase 1 is the rate-limiting enzyme in de novo guanine nucleotide synthesis and contains 2 CBS domains. Positioned at the branch point in adenine/guanine purine de novo synthesis, IMPDH1 catalyzes formation of xanthine monophosphate (XMP) from IMP, the first step in GMP biosynthesis from IMP. Involved in regulation of cell proliferation, inhibition of IMPDH1 activity blocks DNA synthesis and the cell cycle at the G1-S interface. IMPDH1 defects cause RP10. (NCI) ( NCI )]

UMLS (NCI) C1454821

Amino Acid, Peptide, or Protein
Enzyme

Buy website

Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.
Affordable prices from $100.