UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
IVA IVE IVF IVL IVP IVS

IVERMECTIN

[A macrocyclic lactone derived from Streptomyces avermitilis with antiparasitic activity. Ivermectin exerts its anthelmintic effect via activating glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells. Distinct from the channel opening induced by endogenous glutamate transmitter, ivermectin-activated channels open very slowly but essentially irreversibly. As a result, neurons or muscle cells remain at either hyperpolarisation or depolarization state, thereby results in paralysis and death of the parasites. Ivermectin does not readily pass mammal blood-brain barrier to central nervous system where glutamate-gated chloride channels locate, hence the hosts are relatively resistant to the effects of this agent. ( NCI )]
UMLS (NCI) C0022322
 
Organic Chemical
Pharmacologic Substance
Relation/PAR: Anthelminthics
disaccharide
LACTONE
Relation/CHD: IVERMECTIN 6 MG
IVERMECTIN 3 MG

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