I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
Imitation Switch
[The Drosophila gene Imitation SWI (Iswi) encodes a DNA helicase involved in chromatin modeling. It contains a SNF2 related domain, a MYB DNA binding domain, a DEAD/DEAH box helicase, and a helicase C-terminal domain. Iswi is a component of NURF, a nucleosome remodeling complex that facilitates the perturbation of chromatin structure in an ATP-dependent manner. The hydrolysis of ATP during the remodeling of chromatin is mediated by Iswi. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor ACF and of the chromatin accessibility complex CHRAC. This subunit serves as the energy-transducing component of chromatin-remodeling machines. NURF is composed of a 215 kD protein, Iswi, nurf-55, and nurf-38. Iswi belongs to the SNF2/RAD54 helicase family, SNF2L subfamily. (from FlyBase 0011604 and NCI) ( NCI )]
UMLS (NCI) C0253166- Amino Acid, Peptide, or Protein
- Enzyme
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