Immunoglobulin Light Chain, Lambda

[Each antibody molecule is composed of two identical heavy chains and two identical light chains. Immunoglobulin Light Chain Lambda is one of two Ig light chain types. Lambda light chains are encoded by multiple V, J, and C gene segments, which are separated in the genome. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink, OMIM, and NCI) ( NCI )]

UMLS (NCI) C0021037

Amino Acid, Peptide, or Protein
Immunologic Factor

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