I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
Interleukin-1 Receptor-Associated Kinase 1
[Encoded by human IRAK1 Gene (Pelle Ser/Thr Kinase Family), ubiquitous 712-aa 77-kDa Interleukin-1 Receptor-Associated Kinase 1 is one of two putative Ser/Thr kinases that rapidly associate with the Interleukin-1 Receptor (IL1R) upon stimulation. IRAK phosphorylation occurs after association with IL1-R-1, which may activate the kinase. Found in a complex containing TRAF6, PELI1 and IRAK4, IRAK1 interacts with PELI2 and PELI3. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. (NCI) ( NCI )]
UMLS (NCI) C1334201IRAK1
IRAK-1
Pelle Homolog
IRAK-1
Pelle Homolog
- Amino Acid, Peptide, or Protein
- Enzyme
- Immunologic Factor
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