LABETALOL
[A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. ( NCI )]
UMLS (NCI) C0022860- Organic Chemical
- Pharmacologic Substance
Relation/PAR: Ethanolamines
[CV100] BETA-BLOCKERS/RELATED
[CV100] BETA-BLOCKERS/RELATED
Relation/CHD: Labetalol Hydrochloride
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