[A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis. [GOC:rn, PMID:12360190] ( GO )]
UMLS (NCI) C1155748Mitotic Checkpoint