Oral Fluorouracil-Uracil

[A formulated therapeutic oral agent consisting of a combination of tetrahydrofuranyl-5-fluorouracil and uracil (1:4). Tetrahydrofuranyl-5-fluorouracil, the congener prodrug of 5-fluorouracil (5-FU), is metabolized to 5-FU either by hepatic cytochrome P-450 enzymes or by ubiquitous cytosolic enzymes in the body. Because of its higher concentration in the combination, uracil saturates the uracil-reducing enzymatic activity of dihydropyrimidine dehydrogenase, thereby inhibiting first-pass dihydropyrimidine dehydrogenase-mediated hepatic metabolism of the uracil analogue, 5-FU, and permitting prolonged concentration of 5-FU in tumor tissue. 5-FU inhibits the enzyme thymidylate synthase, thereby decreases available thymidine nucleotide. As a result, DNA synthesis is inhibited and tumor cell proliferation is blocked. ( NCI )]

UMLS (NCI) C1446539

Tegafur-Uracil
UFT
Uracil and Ftorafur
Uracil and Tegafur
Uracil and Tetrahydrofuranyl-5-Fluorouracil
Uracil/Tegafur (UFT)

Organic Chemical
Pharmacologic Substance

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