PP2A B Subunit B Prime Epsilon

[Encoded as two isoforms by human PPP2R5E Gene (Phosphatase 2A Regulatory Subunit B Family), serine phosphorylated 55-kD Protein Phosphatase 2 Regulatory Subunit B Epsilon is a regulatory subunit of PP2A. PPP2R5E is predominantly concentrated in the perinuclear cytoplasm and excluded from the nucleus. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )]

UMLS (NCI) C1335545

PP2A B Subunit B56 Epsilon
PP2A B Subunit PR61 Epsilon
PP2A B Subunit R5 Epsilon
PPP2R5E
Protein Phosphatase 2 Regulatory Subunit B Epsilon
Protein Phosphatase 2A Regulatory Subunit B56 Epsilon
Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Epsilon

Amino Acid, Peptide, or Protein
Biologically Active Substance

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