Razoxane

[A bis-dioxopiperazine and a derivative of the chelating agent EDTA with antineoplastic activity. Razoxane, a racemic compound, is able to chelate macromolecules with metal ions, thereby inhibiting enzymes, such as topoisomerase II that require metal ions as cofactors. As a result, the chelating capability may contribute to its antineoplastic properties. Furthermore, this agent has provides cardioprotection against anthracycline toxicity due to its ability to inhibit toxic iron-anthracycline formation. ( NCI )]

UMLS (NCI) C0034738

Organic Chemical
Pharmacologic Substance

Relation/PAR: Piperazines

Relation/CHD: (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione)

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