VAV
[VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and two zinc finger-like domains. VAV also has an SH2, two SH3, and a guanosine exchange factor domain. Truncation of its N-terminus, containing an HLH domain and leucine zipper, activates its oncogenic potential. Wild type VAV is transcribed in hematopoietic cells, including erythroid, lymphoid, and myeloid lineages. VAV-dependent signaling pathways regulate the maturation of T-cells. (from OMIM 164875 and NCI) ( NCI )]
UMLS (NCI) C1451772VAV1
VAV1 Gene Product
VAV1 Protein
VAV1 Gene Product
VAV1 Protein
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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