Zoledronic Acid
[A synthetic imidazole bisphosphonate analog of pyrophosphate with bone-resorption-inhibiting activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This drug also inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. Zoledronic acid's inhibitory effects on osteoclast-mediated bone resorption result in decreased bone turnover and stabilization of the bone matrix, two effects that contribute to the analgesic properties associated with painful osteoblastic lesions. The drug also reduces serum calcium concentrations associated with hypercalcemia. ( NCI )]
UMLS (NCI) C0257685- Organophosphorus Compound
- Pharmacologic Substance
Relation/PAR: ZOLEDRONIC
Unclassified Ingredients
Unclassified Ingredients
Relation/CHD: ZOLEDRONIC ACID 4 MG
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