[Expressed in heart, liver, and skeletal muscle by human VDAC1 Gene (Mitochondrial Porin Family), ubiquitous 282-aa 31-kDa Voltage-Dependent Anion Channel-1 protein consists mainly of membrane-spanning beta-sheets that form a channel in the mitochondrial outer membrane and plasma membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. In response to apoptotic signal transduction, BCL2 proteins regulate cell death by controlling mitochondrial membrane permeability during apoptosis; BCLXL binds to and closes VDAC. Proapoptotic BAX and BAK accelerate VDAC opening, allowing cytochrome C to pass through VDAC, which activates death-driving proteolytic caspases. (NCI) ( NCI )]
UMLS (NCI) C1259712Outer Mitochondrial Membrane Protein Porin-1
Plasmalemmal Porin
Porin
Porin 31HL
Porin 31HM
VDAC-1
Voltage-Dependent Anion Channel-1
Voltage-Dependent Anion-Selective Channel Protein-1
- Amino Acid, Peptide, or Protein
- Biologically Active Substance