UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
M M0 M1 M2 M4 M5 M7 M8 M9 MA MB MC MD ME MF MG MH MI MK ML MM MN MO MP MR MS MT MU MV MY
ME ME ME2 MEA MEB MEC MED MEE MEF MEG MEI MEL MEM MEN MEP MEQ MER MES MET MEV MEX MEZ

2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone

[A sulfonamide derivative and a member of the quinazoline family, chemically related to thiazides, with diuretic, antihypertensive and antiurolithic properties. By blocking Na/Cl transporter, metolazone inhibits electrolyte reabsorption in the distal convoluted tubule and proximal tubule in the kidney. This prevents salt and fluid retention, leading to decreased plasma volume and reduce peripheral resistance of blood vessels, thereby reversal of hypertension. ( NCI )]
UMLS (NCI) C0025854
 
Organic Chemical
Pharmacologic Substance
Relation/PAR: [CV701] THIAZIDES/RELATED DIURETICS
quinazoline
sulfonamide
Relation/CHD: METOLAZONE 0.5 MG
METOLAZONE 10 MG
METOLAZONE 2.5 MG
METOLAZONE 5 MG

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