4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
[A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. ( NCI )]
UMLS (NCI) C0030049- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CN101] OPIOID ANALGESICS
codeine
codeine
Relation/CHD: 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride
Oxycodone Terephthalate
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride
Oxycodone Terephthalate
OXYCODONE 5 MG
Oxycodone Terephthalate
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride
Oxycodone Terephthalate
OXYCODONE 5 MG
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