E2A
[Encoded by human TCF3 Gene, E12 and E47 alternative isoforms of 654-aa 68-kDa nuclear bHLH Transcription Factor 3 are homologous to MYOD, MYC, 'daughterless', 'achaete-scute' and 'twist' families. As a heterodimer with tissue-specific bHLH proteins (e.g., ASH1 and TWIST2), TCF3 determines diverse cell fates during embryogenesis. TCF3 heterodimers bind DNA on CANNTG E-box motifs, such as kappa Ig gene enhancer E2 sites. TCF3 is likely phosphorylated following NGF stimulation. Crucial in dimerization and DNA binding, the bHLH motif forms 2 amphipathic helices that contain highly conserved hydrophobic residues. TCF3 is involved in B-ALL through a t(1;19)(q23;p13.3) translocation and fusion with PBX1. (NCI) ( NCI )]
UMLS (NCI) C1336780E2A Immunoglobulin Enhancer Binding Factor E12
E2A Immunoglobulin Enhancer Binding Factor E47
Immunoglobulin Transcription Factor 1
ITF1
Kappa-E2-Binding Factor
TCF3
Transcription Factor 3
Transcription Factor E2-Alpha
E2A Immunoglobulin Enhancer Binding Factor E47
Immunoglobulin Transcription Factor 1
ITF1
Kappa-E2-Binding Factor
TCF3
Transcription Factor 3
Transcription Factor E2-Alpha
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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