[Containing a TGF-beta family domain, similar to LEFTYA, and encoded by human LEFTB Gene (TGF-Beta Family), secreted 366-amino acid 41-kD Left-Right Determination Factor B (preproprotein) undergoes cell-specific alternative processing into three different products. Processing may occur at R-X-X-R sites. LEFTB appears required for left-right determination during early presomite development in mammals. It may serve as a feedback inhibitor to restrict the range of nodal signaling during establishment of the axis. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1334381Left-Right Determination Factor B
Left-Right Determination Factor B Preproprotein
Lefty 2 Homolog
Lefty-B Protein
- Amino Acid, Peptide, or Protein
- Biologically Active Substance