[Leukemia Inhibitory Factor (LIF), encoded by the LIF gene, is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action is mediated through a high-affinity receptor complex composed of Leukemia Inhibitory Factor Receptor (a low-affinity LIF binding chain) and gp130 (a high-affinity converter subunit). The high-affinity complex also binds oncostatin M, a related cytokine. Both Leukemia Inhibitory Factor Receptor and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (from OMIM) ( NCI )]
UMLS (NCI) C0125607 - Amino Acid, Peptide, or Protein
- Immunologic Factor
- Receptor