[The sulfate salt of a naturally occurring vinca alkaloid. Vincristine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) ( NCI )]
UMLS (NCI) C0042680 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: 22-Oxovincaleukoblastine
Relation/CHD: VINCRISTINE SULFATE 1 MG/ML