MIDODRINE
[A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS). ( NCI )]
UMLS (NCI) C0026078- Organic Chemical
- Pharmacologic Substance
Relation/PAR: Ethanolamines
[CV900] CARDIOVASCULAR AGENTS, OTHER
[CV900] CARDIOVASCULAR AGENTS, OTHER
Relation/CHD: (+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide Monohydrochloride
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