[A synthetic, indolocarbazole protein kinase C (PKC) inhibitor with anti-angiogenic properties. Midostaurin selectively and reversibly binds to and inhibits PKC, thereby inhibiting PKC-mediated signal transduction pathways involved in the regulation of the cell cycle in tumor cells. This may result in cell cycle inhibition and tumor cell apoptosis. ( NCI )]
UMLS (NCI) C0526371 - Organic Chemical
- Pharmacologic Substance