UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
M M0 M1 M2 M4 M5 M7 M8 M9 MA MB MC MD ME MF MG MH MI MK ML MM MN MO MP MR MS MT MU MV MY
MI MIA MIC MID MIF MIG MIK MIL MIM MIN MIO MIP MIR MIS MIT MIU MIV MIW MIX MIZ

Mitochondrial Thymidine Kinase 2

[Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2 Gene (DCK/DGK Family), Thymidine Kinase 2 is a monomeric mitochondrial deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, as well as anti-viral and anti-cancer nucleoside analogs. In nonreplicating cells, mtDNA synthesis depends on 2 salvage pathway deoxyribonucleoside kinases, DGK and Thymidine Kinase 2. Separated from cytosolic dNTPs by the mitochondria inner membrane, mitochondrial dNTPs are maintained by transporter import or deoxynucleoside salvaging; de novo dNTP synthetic enzymes appear not to be present in mitochondria. (NCI) ( NCI )]
UMLS (NCI) C0537740
 
Amino Acid, Peptide, or Protein
Enzyme

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