[Any chemical compound, biological object, physical factor in a concentration or amount that adversely alters the physical, chemical, or biological properties of the environment. The term includes pathogens, toxic metals, carcinogens, oxygen-demanding materials, radiation, natural substances, synthetic industrial chemicals, biocides and all other harmful substances and factors. (NCI) ( NCI )]
UMLS (CSP) C0599786 - Hazardous or Poisonous Substance