- 1. SL11047
- [A second generation polyamine analog synthesized through the restriction of molecular conformations of parent polyamine compounds with potential antineoplastic activity. SL-11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth. ( NCI )] (UMLS (NCI) C0962042) SL-11047 =Organic Chemical; Pharmacologic Substance
| - 2. SL11093
- [A synthetic compound of the polyamine class of chemicals with potential antineoplastic activity. Natural endogenous polyamines bind to DNA and are involved in a number of cellular processes such as cell division, differentiation, and membrane function. SL11093 displaces these polyamines from their DNA binding sites, resulting in cessation of cell growth and cell death. (NCI04) ( NCI )] (UMLS (NCI) C1259818) =Organic Chemical; Pharmacologic Substance ;
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