- 3101. Borst-Jadassohn Intraepidermal Carcinoma
- [A rare cutaneous lesion presenting as a scaly verrucous plaque. Morphologically, the plaque contains nests of basaloid cells. ( NCI )] (UMLS (NCI) C0334260) =Neoplastic Process
| - 3151. bovine ephemeral fever virus
- [The type species of EPHEMEROVIRUS causing disease in cattle. Transmission is by hematophagous arthropods and the virus has been isolated from both culicoides and mosquitoes. ( MSH )] (UMLS (CSP) C0206547) =Virus
|
- 3102. Bortezomib/Carboplatin
- (UMLS (NCI) C1134555) =Therapeutic or Preventive Procedure ;
| - 3152. bovine gamma globulin
- [ ] (UMLS (CSP) C0598471) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 3103. Bortezomib/Carboplatin/Etoposide
- (UMLS (NCI) C1134525) =Therapeutic or Preventive Procedure
| - 3153. Bovine HSP fusion with E7 of HPV16
- [A recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7. Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a number of different cancers. E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes. (NCI04) ( NCI )] (UMLS (NCI) C1327844) HPV 16 E7/HSP65 Vaccine;
HPV E7 Peptide Epitope Vaccine; HspE7; HspE7 Therapeutic Vaccine =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor |
- 3104. Bortezomib/Carboplatin/Gemcitabine
- (UMLS (NCI) C1327839) =Therapeutic or Preventive Procedure; ;
| - 3154. bovine leukemia
- [ ] (UMLS (CSP) C0376408) =Neoplastic Process ;
|
- 3105. Bortezomib/Carboplatin/Paclitaxel
- (UMLS (NCI) C1134560) =Therapeutic or Preventive Procedure ;
| - 3155. bovine leukosis virus
- [ ] (UMLS (CSP) C0319084) =Virus
|
- 3106. Bortezomib/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine
- (UMLS (NCI) C1327921) =Therapeutic or Preventive Procedure ;
| - 3156. bovine mammillitis virus
- [A species of SIMPLEXVIRUS causing mammillitis in cattle in Great Britain and South Africa. ( MSH )] (UMLS (CSP) C0006074) =Virus
|
- 3107. Bortezomib/Dexamethasone
- (UMLS (NCI) C1327816) =Therapeutic or Preventive Procedure ;
| - 3157. bovine papillomavirus
- [causes papillomas on the head and neck and in the mouth and esophagus; injection into hamsters and mice produces fibrosarcomas. ( CSP )] (UMLS (CSP) C0006072) =Virus =Papilloma Virus;
|
- 3108. Bortezomib/Docetaxel
- (UMLS (NCI) C1327805) =Therapeutic or Preventive Procedure ;
| - 3158. Bovine Papillomavirus-1
- [A type of Bovine Papilloma Virus ( NCI )] (UMLS (NCI) C0319145) =Virus
|
- 3109. Bortezomib/Doxorubicin
- (UMLS (NCI) C1134476) Doxorubicin/PS-341 =Therapeutic or Preventive Procedure
| - 3159. bovine papular stomatitis virus
- [ ] (UMLS (CSP) C0319264) =Virus
|
- 3110. Bortezomib/Fludarabine
- (UMLS (NCI) C1328034) =Therapeutic or Preventive Procedure; ;
| - 3160. bovine parvovirus
- [ ] (UMLS (CSP) C0319113) =Virus
|
- 3111. Bortezomib/Fluorouracil/Leucovorin Calcium
- (UMLS (NCI) C0935739) =Therapeutic or Preventive Procedure
| - 3161. bovine serum albumin
- [serum albumin from cows, commonly used in in vitro biological studies. ( CSP )] (UMLS (CSP) C0036774) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=albumin; |
- 3112. Bortezomib/Gemcitabine
- (UMLS (NCI) C1327840) =Therapeutic or Preventive Procedure; ;
| - 3162. bovine syncytial virus
- [ ] (UMLS (CSP) C0079033) =Virus
|
- 3113. Bortezomib/Irinotecan
- (UMLS (NCI) C1327969) =Therapeutic or Preventive Procedure ;
| - 3163. bovine type C oncovirus
- [ ] (UMLS (CSP) C0598028) =Virus ;
|
- 3114. Bortezomib/Mitoxantrone
- (UMLS (NCI) C1328167) =Therapeutic or Preventive Procedure; ;
| - 3164. bovine viral diarrhea virus
- [A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes. ( MSH )] (UMLS (CSP) C0006063) =Virus
|
- 3115. Bortezomib/Oxaliplatin
- (UMLS (NCI) C1328009) =Therapeutic or Preventive Procedure ;
| - 3165. bowel
- [section of the alimentary canal from the stomach to the anus; includes the large and small intestines. ( CSP )] (UMLS (NCI) C0021853) =Body Part, Organ, or Organ Component ;
=Body System, Gastrointestinal; Body Part =Bowel, Large; Bowel, Small; |
- 3116. Bortezomib/Paclitaxel
- (UMLS (NCI) C1134576) =Therapeutic or Preventive Procedure
| - 3166. Bowel burn
- (UMLS (NCI) C1390619) Burn, Bowel =Injury or Poisoning ;
|
- 3117. Bortezomib/Topotecan
- (UMLS (NCI) C1328035) =Therapeutic or Preventive Procedure; ;
| - 3167. Bowel Cancer
- [A primary or metastatic malignant tumor involving the small intestine, large intestine, or both. Representative examples are carcinomas, lymphomas, and sarcomas. — 2004 ( NCI )] (UMLS (NCI) C0346627) =Neoplastic Process
|
- 3118. Borzoi
- [The Borzoi is a tall dog with a long, thin, narrow head. The back is curved. The chest is narrow, but very deep. The longish silky coat may be wavy or with large curls, with a heavy mane at the neck. The colors are white, golden, tan or gray with black markings, in either solid or mixed colors. Height: at least 26-28 inches (71 cm.) Weight: 60-105 pounds (27-48 kg.) ( NCI )] (UMLS (NCI) C0324317) =Mammal
| - 3168. Bowel contents
- (UMLS (HL7) C1546561) =Intellectual Product =Specimen Source Codes;
|
- 3119. Bos bovis
- [use to refer to Bos taurus, a domestic bovine animal regardless of sex or age. ( CSP )] (UMLS (NCI) C0007452) =Mammal ;
=Ungulate; | - 3169. BOWEL DIAGNOST PROC NEC
- [ ] (UMLS (ICD9CM) C0375970) =Diagnostic Procedure
|
- 3120. Boston Terrier
- [Boston Terriers, also called the Boston bull, are compact and well-muscled dogs. Their faces are broad, with a flat head and short, wide muzzle. The hair is short and comes in brindle and white or black and white and some are born brown and white. Height: 15-17 inches (38.1-43 cm.) Weight: 10-25 pounds (4.5-11.3 kg.) ( NCI )] (UMLS (NCI) C0324318) =Mammal
| - 3170. Bowel Dysplasia
- (UMLS (NCI) C1334229) Intestinal Dysplasia;
Intestinal Intraepithelial Neoplasia; =Neoplastic Process |
- 3121. Boswellia
- [B. serrata is a tree from the Burseraceae family commonly found in India, northern Africa and the Middle East. Strips of its bark yield a gummy oleoresin which contains oils, terpenoids and gum. Its active principle consists of 4 pentacyclic triterpenes, beta-boswellic acid being the major one. Extracts of this oleoresin have been used as a folk medicine for centuries in Ayurdevic medicine in India. Boswellic acids have anti-inflammatory properties inhibiting leukotriene biosynthesis via non-competitive inhibition of 5-lipoxygenase. Boswellia extract tablets have been employed for asthma, arthritic conditions and ulcerative colitis and other chronic inflammatory diseases. ( NCI )] (UMLS (NCI) C0949991) Boswellia serrata;
Frankincense; =Plant ; | - 3171. bowel lavage
- [ ] (UMLS (CSP) C0150154) =Therapeutic or Preventive Procedure
|
- 3122. BOT
- [A vessel with a narrow neck designed to accept a specific closure. ( NCI )] (UMLS (NCI) C0179376) =Manufactured Object
| - 3172. bowel movement
- [The normal process of elimination of fecal material from the rectum. ( NCI )] (UMLS (CSP) C0011135) =Organism Function ;
|
- 3123. Botanical Therapy
- [Therapy based on plant-derived preparations which include the following: Individual herbs - Ginkgo biloba, Hypericum, Garlic, Ginseng, Echinacea, Saw palmetto, Urtica diocia (nettle), Kava kava, Hawthorne, Witch Hazel, Bilberry, Ginger, Aloe vera, Capsicum, Feverfew, Green tea, Tee Tree oil, Licorice root, Yohimbe, Valerian, Bee Pollen, Cat's Claw, Evening Primrose, Dong Quai, Fenugreek, Marshmallow, Psyllium, Tumeric. Combinations include: Padma 28, Hoxey, Essiac, Saw palmetto, Pygeum africanum. ( NCI )] (UMLS (NCI) C0242388) =Therapeutic or Preventive Procedure ;
| - 3173. Bowel Obstruction
- [any impairment, arrest, or reversal of the normal flow of intestinal contents toward the anus. ( CSP )] (UMLS (NCI) C0021843) =Acquired Abnormality; Disease or Syndrome =Intestinal Diseases;
=Afferent Loop Syndrome; Duodenal Obstruction; Feces, Impacted; Intestinal Pseudo-obstruction; INTUSSUSCEPTION; |
- 3124. Botany
- [Botany; the branch of biology that studies plants. ( NCI )] (UMLS (NCI) C0006038) =Occupation or Discipline ;
| - 3174. Bowel Obstruction Management
- (UMLS (NCI) C0879425) =Therapeutic or Preventive Procedure
|
- 3125. Both HL7 mandated and the original code
- [Both HL7 mandated and the original code (precoordination) ( HL7V3.0 )] (UMLS (HL7) C1552075) =Idea or Concept =CodingRationale;
| - 3175. Bowel Perforation
- [Opening or penetration through the wall of the INTESTINES. ( MSH )] (UMLS (NCI) C0021845) =Acquired Abnormality; Disease or Syndrome =Intestinal Diseases;
|
- 3126. Both hospital and physician
- (UMLS (HL7) C1548535) =Idea or Concept =Coverage Type;
| - 3176. Bowel Preparation
- (UMLS (NCI) C0455052) =Health Care Activity
|
- 3127. botox
- [ ] (UMLS (CSP) C0700702) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 3177. Bowel Resection
- [Surgical removal of part or all of the intestine. ( NCI )] (UMLS (NCI) C0741614) Intestine Resection =Therapeutic or Preventive Procedure
|
- 3128. BOTPL
- [A plastic vessel with a narrow neck designed to accept a specific closure. ( NCI )] (UMLS (NCI) C0727492) BOTTLE, PLASTIC;
Plastic Bottle =Medical Device ; =Bottle; =Polyethylene Bottle | - 3178. Bowel, Large
- [segment of the lower gastrointestinal tract that includes the cecum, the colon and the rectum. ( CSP )] (UMLS (HL7) C0021851) =Body Part, Organ, or Organ Component ;
=bowel; Body Part =colon; rectum/anus; ileocolonic region; |
- 3129. Botryoid Sarcoma
- [A morphologic variant of embryonal rhabdomyosarcoma arising from organs with a mucosal epithelial surface. It is characterized by the formation of a cambium layer in the affected tissue and polypoid nodules within an abundant myxoid stroma. ( NCI )] (UMLS (NCI) C1306573) Botryoid-Type Embryonal Rhabdomyosarcoma;
Sarcoma Botryoides; =Neoplastic Process | - 3179. Bowel, Small
- [proximal part of the intestine, extending from the pylorus to the cecum; about twenty feet long in humans. ( CSP )] (UMLS (HL7) C0021852) =Body Part, Organ, or Organ Component ;
=bowel; Body Part =duodenum; Ileum; Jejunum |
- 3130. Bottle
- [A container, typically rounded, either glass or plastic with a narrow neck and capable of storing liquid. ( HL7V3.0 )] (UMLS (HL7) C1556078) =Intellectual Product =MultiUseContainerEntityType;
=BOTPL; Amber Bottle; Dropper Bottle; Glass Bottle; | - 3180. Bowen Disease
- [(BO-uns disease) A skin disease marked by scaly or thickened patches on the skin and often caused by prolonged exposure to arsenic. The patches often occur on sun-exposed areas of the skin and in older, white men. These patches may become malignant (cancerous). Also called precancerous dermatosis or precancerous dermatitis. ( NCI )] (UMLS (NCI) C0006079) =Neoplastic Process =Carcinoma, Squamous Cell;
|
- 3131. bottom
- (UMLS (HL7) C1552825) =Idea or Concept =TableCellVerticalAlign;
| - 3181. Bowen Disease of the Penis
- [Stage 0 includes: (Tis, N0, M0) and (Ta, N0, M0). Tis: Carcinoma in situ. Ta: Non-invasive verrucous carcinoma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) ( NCI )] (UMLS (NCI) C0154089) =Neoplastic Process
|
- 3132. Bottom Rule
- [Render cell with rule on bottom ( HL7V3.0 )] (UMLS (HL7) C1552587) =Functional Concept =Table Rule Style;
| - 3182. Bowenoid Papulosis
- (UMLS (NCI) C0334106) =Neoplastic Process
|
- 3133. botulin
- [toxins produced by Clostridium botulinum; there are at least seven different substances, most being proteins; they have neuro-, entero-, and hemotoxic properties, are immunogenic, and are among the most potent poisons known; used medically to block release of acetylcholine at cholinergic synapses. ( CSP )] (UMLS (CSP) C0006055) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =exotoxin;
[MS900] MUSCULOSKELETAL AGENTS, OTHER; [OP900] OPHTHALMICS, OTHER; Unclassified Ingredients =BOTULINUM TOXIN TYPE A; BOTULINUM TOXIN TYPE B; BOTULINUM TOXIN TYPE A; BOTULINUM TOXIN TYPE B | - 3183. Bowman's Capsule
- [A double-walled epithelial capsule that is the bulbous closed proximal end of the kidney tubular system. It surrounds the cluster of convoluted capillaries of KIDNEY GLOMERULUS and is continuous with the convoluted PROXIMAL KIDNEY TUBULE. ( MSH )] (UMLS (NCI) C0524448) =Body Part, Organ, or Organ Component
|
- 3134. botulinum antitoxin
- [botulinum antitoxin ( HL7V3.0 )] (UMLS (HL7) C0006044) =Organic Chemical; Pharmacologic Substance; Immunologic Factor =[IM300] ANTIVENINS/ANTITOXINS;
Unclassified Ingredients; Vaccines administered (code = CVX)(parenteral, unless oral is noted); VaccineType =BOTULISM ANTITOXIN 5000 UNT; | - 3184. Bowman's Membrane
- [A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. ( NCI )] (UMLS (NCI) C0229127) =Body Part, Organ, or Organ Component
|
- 3135. botulism
- [disease caused by potent protein neurotoxins produced by Clostridium botulinum, which interfere with the presynaptic release of acetylcholine at the neuromuscular junction; clinical features include abdominal pain, vomiting, acute paralysis, blurred vision and diplopia; botulism may be classified into several subtypes such as food borne, infant, wound, and others. ( CSP )] (UMLS (CSP) C0006057) =Injury or Poisoning =clostridial infection;
food poisoning; bacterial food poisoning; Neurotoxicity; Neuromuscular Junction Diseases; | - 3185. Bowman's Space
- (UMLS (NCI) C0227643) =Body Space or Junction
|
- 3136. BOTULISM FOOD POISONING
- [ ] (UMLS (ICD9CM) C1955640) =Injury or Poisoning
| - 3186. box
- (UMLS (HL7) C1552831) =Idea or Concept =TableFrame;
|
- 3137. Bouillaud disease
- [ ] (UMLS (CSP) C0085916) =Disease or Syndrome ;
| - 3187. Box
- [A 6-sided container commonly made from paper or cardboard used for solid forms. ( HL7V3.0 )] (UMLS (HL7) C1579850) =Intellectual Product =MultiUseContainerEntityType;
|
- 3138. Bouin's solution
- [A general purpose reagent is a chemical reagent that has general laboratory application, that is used to collect, prepare, and examine specimens from the human body for diagnostic histopathology, cytology, and hematology, and that is not labeled or otherwise intended for a specific diagnostic application. General purpose reagents include cytological preservatives, decalcifying reagents, fixatives and adhesives, tissue processing reagents, isotonic solutions, and pH buffers. ( SPN )] (UMLS (HL7) C0053963) =Organic Chemical; Biomedical or Dental Material ;
=Additive/Preservative; | - 3188. Box
- [A square or rectangular vessel, usually made of cardboard or plastic. ( NCI )] (UMLS (NCI) C0179400) =Manufactured Object
|
- 3139. Bouin's solution
- [Picric acid, saturated aqueous solution (750.0 ml), 37-40% formalin (250.0 ml), glacial acetic acid (50.0 ml). Tissue preservative. ( HL7V3.0 )] (UMLS (HL7) C1550054) =Intellectual Product ;
=MaterialEntityAdditive; | - 3189. Boxer
- [The Boxer's body is compact and powerful with a close-fitting coat that comes in fawn, brindle, white and various shades of red, with white markings. Its head is in proportion to its body, lean and unwrinkled. Its lower jaw extends beyond its upper one, curving upward. Height: 21-25 inches (53-63 cm.) Weight: 53-70 pounds (24-32 kg.) ( NCI )] (UMLS (NCI) C0324320) =Mammal
|
- 3140. bounded ROI
- [A Region of Interest (ROI) specified for a multidimensional observation, such as an Observation Series (OBSSER). The ROI is specified using a set of observation criteria, each delineating the boundary of the region in one of the dimensions in the multidimensional observation. The relationship between a ROI and its referenced Act is specified through an ActRelationship of type subject (SUBJ), which must always be present. Each of the boundary criteria observations is connected with the ROI using ActRelationships of type "has component" (COMP). In each boundary criterion, the Act.code names the dimension and the Observation.value specifies the range of values inside the region. Typically the bounded dimension is continuous, and so the Observation.value will be an interval (IVL) data type. The Observation.value need not be specified if the respective dimension is only named but not constrained. For example, an ROI for the QT interval of a certain beat in ECG Lead II would contain 2 boundary criteria, one naming the interval in time (constrained), and the other naming the interval in ECG Lead II (only named, but not constrained). ( HL7V3.0 )] (UMLS (HL7) C1555572) =Idea or Concept =ActClassROI;
| - 3190. BP
- [A group of islands in the South Pacific Ocean, east of Papua New Guinea. (NCI) ( NCI )] (UMLS (NCI) C0037623) =Geographic Area ;
|
- 3141. Bourneville's disease
- [autosomal dominant disease characterized principally by the presences of hamartomas of the brain, retina, and visera; clinical manifestations include mental retardation, seizures, and adenoma sebaceum of the face. ( CSP )] (UMLS (CSP) C0041341) =Neoplastic Process ;
=hamartoma; Genetic Condition; Arrieration mentale; Neurocutaneous Syndromes; congenital brain disorder; Heredodegenerative Disorders, Nervous System | - 3191. BP Observation Status Codes Interpretation
- (UMLS (HL7) C1547886) =Idea or Concept =HL7 Vocabulary Version 2.5;
=Post original as wrong, e.g., transmitted for wrong patient; Record coming over is a correction and thus replaces a final status; Deletes the BPX record; "Final status; Can only be changed with a corrected status" ;Order detail description only (no status); Preliminary status; |
- 3142. BOUTONNEUSE FEVER
- [A febrile disease of the Mediterranean area, the Crimea, Africa, and India, caused by infection with RICKETTSIA CONORII. ( MSH )] (UMLS (ICD9CM) C0006060) =Disease or Syndrome =Rickettsia Infections;
Tick-Borne Diseases | - 3192. BPD
- [chronic lung disease of infants, possibly related to oxygen toxicity or barotrauma, characterized by bronchiolar metaplasia and interstitial fibrosis. ( CSP )] (UMLS (CSP) C0006287) =Disease or Syndrome ;
=Infant, Premature, Diseases; Lung Diseases |
- 3143. BOUTONNIERE DEFORMITY
- [ ] (UMLS (ICD9CM) C0158476) =Acquired Abnormality ;
| - 3193. BPH NOS W UR OBS/LUTS
- [ ] (UMLS (ICD9CM) C1260426) Hyperplasia of prostate, unspecified, with urinary obstruction and other lower urinary symptoms (LUTS) =Disease or Syndrome
|
- 3144. Bouviers Des Flandres
- [The Bouviers Des Flandres is a powerful dog with a massive and heavily-coated head with a thick beard and mustache and shaggy eyebrows. It has a double coat, and the rough, shaggy-looking outer coat is harsh and dry to the touch. This steel-wool hair comes in black, fawn, gray, or brindle. Height: 22-28 inches (56-71 cm.) Weight: 60-90 pounds (27-41 kg.) ( NCI )] (UMLS (NCI) C0324319) =Mammal
| - 3194. BPH NOS W/O UR OBS/LUTS
- [ ] (UMLS (ICD9CM) C1719540) Hyperplasia of prostate, unspecified, without urinary obstruction and other lower urinary symptoms (LUTS) =Disease or Syndrome
|
- 3145. Bovidae
- [Taxonomic family which includes domestic cattle, goats, and sheep. ( NCI )] (UMLS (CSP) C1265545) =Mammal
| - 3195. BPH W URINARY OBS/LUTS
- [ ] (UMLS (ICD9CM) C1260419) Hypertrophy (benign) of prostate with urinary obstruction and other lower urinary tract symptoms (LUTS) =Disease or Syndrome
|
- 3146. bovine
- [ ] (UMLS (CSP) C1140701) =Mammal ;
| - 3196. BPH W/O URINARY OBS/LUTS
- [ ] (UMLS (ICD9CM) C1719538) Hypertrophy (benign) of prostate without urinary obstruction and other lower urinary tract symptoms (LUTS);
=Disease or Syndrome |
- 3147. bovine alphaherpesvirus 1
- [ ] (UMLS (CSP) C0597799) =Virus ;
| - 3197. BPS _ Blood product dispense status
- (UMLS (HL7) C1549265) =Health Care Activity =Event Type;
|
- 3148. bovine alphaherpesvirus 2
- [ ] (UMLS (CSP) C0597797) =Virus ;
| - 3198. BR
- [A country in Eastern South America, bordering the Atlantic Ocean. (NCI) ( NCI )] (UMLS (NCI) C0006137) =Geographic Area =South America;
|
- 3149. Bovine Cartilage
- [Cartilage extracted from various parts of a cow and is proposed to stimulate the immune system and inhibit tumor cell growth. It was used in the 1950s and 60s to enhance wound healing. (NCI) ( NCI )] (UMLS (NCI) C0106940) =Organic Chemical; Pharmacologic Substance
| - 3199. Br element
- [halogen element with the atomic symbol Br, atomic number 36, and atomic weight 79.904; a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested. ( CSP )] (UMLS (CSP) C0006223) =Hazardous or Poisonous Substance; Element, Ion, or Isotope ;
=halogen; |
- 3150. bovine coronavirus
- [A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death. ( MSH )] (UMLS (CSP) C0027610) =Virus
| - 3200. BR96 sFv-PE40
- [A single-chain immunotoxin consisting of Fv fragments of the BR96 monoclonal antibody (MoAb) and a truncated Pseudomonas exotoxin (PE40) that lacking the binding domain. MoAb BR96 specifically binds to Lewis Y-related carbohydrate antigen, a cell surface antigen overexpressed in many carcinomas. After internalization, PE40 causes ADP-ribosylation of transcription elongation factor 2, thereby inactivating elongation factor 2 and inhibiting protein synthesis in the cancer cells. ( NCI )] (UMLS (NCI) C0259637) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|