2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-Dioxide

[A sulfonamide derivative and a synthetic thiazide with diuretic, antihypertensive and anti-urolithic properties. By blocking the Na/Cl transporter, polythiazide inhibits reabsorption of sodium and chloride in the proximal and distal convoluted tubule of the kidney, resulting in increased excretion of water and electrolytes (sodium, potassium, chloride, magnesium, and bicarbonate) and subsequent reversal of hypertension. In addition, this agent exerts its anti-urolithic effect by decreasing calcium and uric acid excretion. ( NCI )]

UMLS (NCI) C0032613