A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
AGO Protein
[Encoded by human FBXW7 Gene, alpha and beta AGO Protein (F-Box Family), 707 and 627 amino acids respectively, differ in their N-termini and contain the putative functional F box and seven WD repeats. F-box proteins constitute one of four SCF subunits of the ubiquitin protein ligase complex, involved in phosphorylation-dependent ubiquitination. AGO protein binds to cyclin E, and probably targets it for ubiquitin-mediated degradation. AGO mutant cells have elevated levels of cyclin E without increased cyclin E mRNA levels. Homologue of Cdc4 (S. cerevisiae) and Archipelago (Drosophila), human AGO also has low similarity to Met30p (S. cerevisiae). Drosophila and human AGO are 78% identical. AGO may represent a mutational target in ovarian cancer. (from OMIM and NCI) ( NCI )]
UMLS (NCI) C0755295Archipelago Homologue Protein
F-box and WD-40 domain protein 7
F-box protein FBW7
FBXW7
FBXW7 Protein
F-box and WD-40 domain protein 7
F-box protein FBW7
FBXW7
FBXW7 Protein
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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