ALPS2

[Caspase-10, encoded by the CASP10 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-10 is involved in the activation cascade of caspases responsible for apoptosis execution. It is recruited to both FAS- and TNFR-1 receptors in a FADD dependent manner. Caspase-10 cleaves and activates Caspases-3, -4, -6, -7, -8, and -9, and itself can be processed by Caspase-8. Mutations in the CASP10 gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. (From LocusLink, Swiss-Prot and NCI) ( NCI )]

UMLS (NCI) C0758959

Apoptotic Protease MCH-4
CASP10
CASP10 Protein
Caspase 10, Apoptosis-Related
Caspase 10, Apoptosis-Related Cysteine Protease
Caspase-10
Cysteine Protease
EC 3.4.22.-
FADD-Like ICE2
Fas-Associated Death Domain Protein
FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2
FLICE2
ICE-Like Apoptotic Protease 4
Interleukin-1B-Converting Enzyme 2
MCH4

Amino Acid, Peptide, or Protein
Enzyme

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