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Aceglatone
[A derivative of D-glucaro-1, 4-lactone with chemopreventive and anti-tumor activities. The active metabolite of aceglatone, D-glucaro-1,4-Lactone, is an inhibitor of beta-glucuronidase, an enzyme produced by intestinal colonic micro-flora and hydrolyzing glycosidic bonds in glucuronides. One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by glucuronidation. When beta-glucuronidase deconjugated these glucuronides, it prolongs the stay of the hormone or toxic chemical in the body. Elevated beta-glucuronidase activity has been implicated to be associated with an increased risk for hormone-dependent cancers like breast, prostate, and colon cancers. Thereby, aceglatone may suppress the developments of hormone-dependent cancers mediated through beta-glucuronidase inhibition. ( NCI )]
UMLS (NCI) C0050406- Organic Chemical
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