A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
Acute Myelogenous Leukemia 1 Translocation 1 Protein MTG8A
[Encoded by human CBFA2T1 Gene, conserved 604-aa 67.6-kD ETO Protein is a putative MYND zinc finger transcription factor expressed as multiple isoforms in brain, heart, lung, pituitary, skeletal muscle, pancreas, placenta, testis, and ovary. MTG8B and MTG8C variants have distinct N-termini. One frameshifted MTG8 variant lacks C-terminal zinc fingers, a P/S/T-rich domain, and a coiled-coil structure. In AML-M2, t(8;21)(q22;q22) in stem cells produces a fused chimeric RUNX1-CBFA2T1 protein. Associated with NCOR/HDAC, this protein may repress transcription and differentiation in hematopoietic precursors. p14(ARF) may be a target of AML1-ETO. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0218234- Amino Acid, Peptide, or Protein
- Biologically Active Substance
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
