A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
Acute Myeloid Leukemia-1/Eight-Twenty-One Protein
[In acute myeloid leukemia, the frequent t(8;21)(q22;q22) translocation produces a chimeric AML1/ETO gene. Association of the AML1/ETO product with the NCOR/HDAC complex blocks hematopoietic differentiation. The interaction requires ETO coiled-coil regions and is responsible for abnormal recruitment of NCOR, transcriptional repression, and impaired differentiation of primary hematopoietic precursors. AML1/ETO transcripts are present in a fraction of stem cells, monocytes, marrow B-cells, and in colony-forming cells of erythroid, granulocyte-macrophage, and/or megakaryocyte lineages, but not in T-cells. (from OMIM 133435 and NCI) ( NCI )]
UMLS (NCI) C1332085AML-1/ETO
- Amino Acid, Peptide, or Protein
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
