[Ubiquitously expressed by human EXTL2 Gene (EXT Family), 330-aa 37.5-kDa Exostosin-Like 2 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI) ( NCI )]
UMLS (NCI) C1308415Alpha-GalNAcT EXTL2
Exostosin-Like 2 Protein
EXTL2
EXT-Related Protein 2
- Amino Acid, Peptide, or Protein
- Enzyme