[Encoded by human IFNAR1 Gene (Type II Cytokine Receptor Family), 557-aa 64-kDa (precursor) ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Alpha Chain contains 3 fibronectin type III domains and is the alpha subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI) ( NCI )]
UMLS (NCI) C0380190 - Amino Acid, Peptide, or Protein
- Receptor