[An ethanolamine derivative with antihistaminic property. Phenyltoloxamine blocks H1 histamine receptors, thereby inhibiting phospholipase A2 and production of endothelium-derived relaxing factor, nitric oxide. Subsequent lack of activation of guanylyl cyclase through nitric oxide results in decreased cyclic GMP levels, thereby inhibiting smooth muscle constriction of various tissues, decreasing capillary permeability and decreasing other histamine-activated allergic reactions. ( NCI )]
UMLS (NCI) C0070709 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: Benzhydryl Compounds
[AH900] ANTIHISTAMINES, OTHER
Relation/CHD: PHENYLTOLOXAMINE CITRATE
PHENYLTOLOXAMINE RESIN COMPLEX
PHENYLTOLOXAMINE CITRATE
PHENYLTOLOXAMINE RESIN COMPLEX
PHENYLTOLOXAMINE 10 MG/5ML
PHENYLTOLOXAMINE 50 MG
PHENYLTOLOXAMINE 30 MG
PHENYLTOLOXAMINE DIHYDROGENCITRATE
PHENYLTOLOXAMINE RESINCOMPLEX
PHENYLTOLOXAMINECITRATE
PHENYLTOLOXAMINEDIHYDROGEN CITRATE