BAI1

1. [This gene plays a role in signal transduction and negative regulation of cell proliferation. It is involved in both development and inhibition of angiogenesis. ( NCI )]
   UMLS (NCI) C1332374
   
   BAI1 Gene
   Brain-Specific Angiogenesis Inhibitor 1 Gene
    

   Gene or Genome
   

2. [BAI1 is a a seven-span transmembrane protein and is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. (LocusLink) ( NCI )]
   UMLS (NCI) C1332603
   
   Brain-specific Angiogenesis Inhibitor 1
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance