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[The sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05) ( NCI )]
UMLS (NCI) C0733440FOSINOPRIL SODIUM
FOSINOPRIL SODIUM PREPARATION
L-proline, 4-Cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxyl](4-phenylbutyl) phosphinyl]acetyl]-,Sodium Salt, trans-
FOSINOPRIL SODIUM PREPARATION
L-proline, 4-Cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxyl](4-phenylbutyl) phosphinyl]acetyl]-,Sodium Salt, trans-
- Organophosphorus Compound
- Pharmacologic Substance
Relation/PAR: FOSINOPRIL
Relation/CHD: FOSINOPRIL SODIUM 10 MG
FOSINOPRIL SODIUM 20 MG
FOSINOPRIL SODIUM 40 MG
FOSINOPRIL SODIUM 20 MG
FOSINOPRIL SODIUM 40 MG
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