[The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. ( NCI )]
UMLS (NCI) C0014922 - Steroid
- Pharmacologic Substance
Relation/PAR: 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-[bis(2-chloroethyl)carbamate]
Relation/CHD: ESTRAMUSTINE PHOSPHATE SODIUM 140 MG