P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
PP2A-Alpha
[Encoded by human PPP2CA Gene (PP1 Family), 309-aa 36-kDa cytoplasmic Protein Phosphatase 2 Catalytic Subunit Alpha forms alpha complexes with a structural PR65/A subunit and beta complexes with an alpha4 protein; association with a regulatory subunit that controls substrate selectivity and activity forms as a specific trimeric holoenzyme. PPP2CA is regulated by inactivating threonine or tyrosine phosphorylation, carboxy methylation, ceramide, and protein inhibitors. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. Core PP2A enzyme consists of the catalytic subunit and a common 65-kDa regulatory subunit; additional regulatory subunits or signaling molecules further modify function. (NCI) ( NCI )]
UMLS (NCI) C1335539PP2CA
PPP2CA
Protein Phosphatase 2 Catalytic Subunit Alpha
Replication Protein C
RP-C
Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha
PPP2CA
Protein Phosphatase 2 Catalytic Subunit Alpha
Replication Protein C
RP-C
Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha
- Amino Acid, Peptide, or Protein
- Enzyme
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