P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
Polyubiquitin B
[Encoded by human UBB Gene, highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin B is synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. UBB appears to be covalently bound to proteins as a marker for degradation, but also binds to histone H2A in actively transcribed regions and does not cause histone H2A degradation; UBB may be involved in regulation of gene expression. (NCI) ( NCI )]
UMLS (NCI) C1313661UBB
Ubiquitin B
Ubiquitin B
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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