[Encoded by human PTPN1 Gene (Non-Receptor PTP Family), 435-aa 50-kDa Non-Receptor Type 1 Protein Tyrosine Phosphatase is a negative regulator of insulin signaling by dephosphorylating insulin receptor kinase and is associated with the endoplasmic reticulum via its C-terminal domain and its phosphatase domain oriented towards the cytoplasm. PTPN1 may also dephosphorylate EGFR kinase, as well as JAK2 and TYK2 kinases, suggesting a role in cell growth control, and cell response to interferon stimulation. Protein Tyrosine Phosphatases typically regulate cellular processes such as cell growth, differentiation, and mitotic cycle. Oxidation of Cys-215 forms a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity; the active site is restored by reduction. (NCI) ( NCI )]
UMLS (NCI) C1335056PTPN1
- Amino Acid, Peptide, or Protein
- Enzyme