- 1. Ewing Family of Tumors
- [malignant tumor of bones which always arises in medullary tissue, occurring more often in cylindrical bones, with pain, fever, and leukocytosis. ( CSP )] (UMLS (NCI) C0553580) =Neoplastic Process ;
=bone neoplasm;
Osteogenic Sarcoma;
Connective Tissue Sarcoma;
| - 5. Ewing's Sarcoma, Localized
- [Ewing sarcoma which has not spread from its initial site. ( NCI )] (UMLS (NCI) C0863029) Localized Ewing Sarcoma;
Localized Ewing's Sarcoma;
Localized Ewing's Tumor =Neoplastic Process |
- 2. Ewing Sarcoma Breakpoint Region 1 Gene
- [This gene may play a role in post-transcriptional regulation; however the function remains to be elucidated. Mutations in the gene result in Ewing sarcoma and other tumors. ( NCI )] (UMLS (NCI) C0808901) EWSR1;
EWSR1 Gene =Gene or Genome ;
| - 6. Ewing's Sarcoma, Metastatic
- [Ewing sarcoma which has spread from its initial site. ( NCI )] (UMLS (NCI) C0278586) =Neoplastic Process
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- 3. Ewing Sarcoma Breakpoint Region 1 Protein
- [Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA recognition motif and a RANBP2-type zinc finger, and may function as a repressor. EWS contains a transcription activation domain, but the RNA-binding domain can repress trans-activation by the activation domain. The RNA-binding activity is localized to a C-terminal RGG box. EWS binds RNA, calmodulin, and the RNA polymerase II 33 kD polypeptide (RPB3), but not RPB5 or RPB7. EWS interacts with FAK2 and relocates from cytoplasm to ribosomes upon FAK2 activation. Two isoforms of the EWS protein are produced by differential splicing. (from SWISS-PROT Q01844 and NCI) ( NCI )] (UMLS (NCI) C0288194) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 7. Ewing's Sarcoma, Recurrent
- [Ewing sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy. ( NCI )] (UMLS (NCI) C0278590) =Neoplastic Process
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- 4. Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor of Bone
- [A spectrum of malignant tumors arising from the bone, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. Pain and the presence of a mass are the most common clinical symptoms. — 2004 ( NCI )] (UMLS (NCI) C1333481) Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor of Bone =Neoplastic Process ;
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