- 1. MCM Protein
- [The MCM proteins are essential replication initiation factors. The best known among them are a family of six structurally related proteins, MCM2-7, which are evolutionally conserved in all eukaryotes. The MCM2-7 proteins form a hexameric complex. This complex is a key component of the prereplication complex that assembles at replication origins during early G1 phase. The MCM2-7 proteins may be involved not only in the initiation but also in the elongation of DNA replication. Orchestration of the functional interactions between the MCM2-7 proteins and other components of the prereplication complex by cell cycle-dependent protein kinases results in initiation of DNA synthesis once every cell cycle. (from PMID 10872463 and NCI) ( NCI )] (UMLS (NCI) C1334495) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 7. MCM5
- [This gene is involved in the initiation and licensing of DNA replication. It also plays a role in the regulation of transcriptional activation. ( NCI )] (UMLS (NCI) C1334492) MCM5 Gene;
MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 (S. Cerevisiae) Gene;
=Gene or Genome ;
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- 2. MCM10
- [This gene plays a role in DNA replication during progression through the S phase of the cell cycle. ( NCI )] (UMLS (NCI) C1334488) MCM10 Gene;
MCM10 Minichromosome Maintenance Deficient 10 (S. Cerevisiae) Gene;
=Gene or Genome ;
| - 8. MCM6
- [This gene plays a role in the initiation and licensing of DNA replication. ( NCI )] (UMLS (NCI) C1334493) MCM6 Gene;
MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae) Gene;
=Gene or Genome ;
|
- 3. MCM10 Homolog
- [Encoded by human MCM10 Gene, 98-kD Minichromosome Maintenance Protein 10 binds chromatin during S phase, dissociates in G(2), and is involved in eukaryotic genome replication initiation. MCM10 is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. MCM10 interacts with ORC2 and with MCM2 and MCM6 of the hexameric MCM2-7 protein complex, a key component of the pre-replication complex and likely involved in formation of replication forks and in recruitment of replication factors. Involved in S phase progression, MCM10 may release MCM2-7 from the origin of replication triggering DNA replication. MCM10 likely binds chromatin after pre-RC assembly and before origin unwinding. (NCI) ( NCI )] (UMLS (NCI) C1334765) Minichromosome Maintenance Protein 10;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 9. MCM7
- [This gene is involved in the initiation and licensing of DNA replication. It also plays a role in cell cycle inhibition following DNA damage. ( NCI )] (UMLS (NCI) C1334494) MCM7 Gene;
MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae) Gene;
=Gene or Genome ;
|
- 4. MCM2
- [This gene plays a role in the initiation of DNA replication. It is also involved in cell cycle control and cell proliferation. ( NCI )] (UMLS (NCI) C1334489) MCM2 Gene;
MCM2 Minichromosome Maintenance Deficient 2, Mitotin (S. Cerevisiae) Gene;
=Gene or Genome ;
| - 10. mcmol/24h
- (UMLS (NCI) C0439436) =Quantitative Concept
|
- 5. MCM3
- [This gene is involved in regulation of DNA replication by ensuring that DNA is replicated only once during the cell cycle. It also plays a role in cell proliferation. ( NCI )] (UMLS (NCI) C1334490) MCM3 Gene;
MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) Gene;
=Gene or Genome ;
| - 11. mcmol/dL
- [Unit of concentration (molarity unit) equal to one millionth of mole of a solute in one deciliter of the solution. ( NCI )] (UMLS (NCI) C0439280) =Quantitative Concept
|
- 6. MCM4
- [This gene plays a role in the cell cycle control of DNA replication. ( NCI )] (UMLS (NCI) C1334491) MCM4 Gene;
MCM4 Minichromosome Maintenance Deficient 4 (S. Cerevisiae) Gene;
=Gene or Genome ;
| |
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