1-Phosphatidylinositol Phosphodiesterase

[Encoded by human PLCG2 Gene, 1265-aa 148-kDa Phospholipase C Gamma 2 is a crucial enzyme that generates DAG and IP3 second messengers in the transmembrane signaling of ligand-activated growth factor receptors. Containing a PI-PLC X-box catalytic domain, a PI-PLC Y-box catalytic domain, a C2 domain, a PH domain, 2 SH2 domains, and an SH3 domain, PLCG2 phospholipase activity increases upon phosphorylation on tyrosine residues following activation of growth factor and immune system receptors. (NCI) ( NCI )]

UMLS (NCI) C1377870

1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 2
EC 3.1.4.11
Phosphatidylinositol-Specific Phospholipase C-Gamma
Phosphoinositide Phospholipase C
Phospholipase C Gamma 2
Phospholipase C, Gamma 2 (Phosphatidylyinositol-specific)
Phospholipase C-Gamma-2
PI-Specific PLC Gamma
PLCG2
PLC-Gamma-2
PLC-IV

Amino Acid, Peptide, or Protein
Enzyme

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