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Anti-Dopamine-b-Hydroxylase Monoclonal Antibody-Saporin
[An immunoconjugate of the anti-dopamine-b-hydroxylase monoclonal antibody covalently linked to the ribosome-inactivating protein (RIP) saporin derived from Saponaria officinalis. The monoclonal antibody component recognizes and attaches to the membrane-associated antigen, dopamine-b-hydroxylase, resulting in the conjugate being internalized by receptor-mediated endocytosis. The saporin toxin is then released from the complex, and binds to ribosomal subunits, thereby halts protein synthesis, and results in cell death. This immunoconjugate targets the dopamine-beta-hydroxylase enzyme localized on adrenergic nerves in the brainstem particular medulla and pons, thereby could be used to study neurodegenerative disorders and/or address fundamental neurobiological questions. ( NCI )]
UMLS (NCI) C1510925DSAP
- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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