Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, Monohydrochloride

[The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction. ( NCI )]

UMLS (NCI) C0600311

Organic Chemical
Pharmacologic Substance

Relation/PAR: PROCAINAMIDE

Relation/CHD: PROCAINAMIDE HYDROCHLORIDE 250 MG
PROCAINAMIDE HYDROCHLORIDE 375 MG
PROCAINAMIDE HYDROCHLORIDE 500 MG
PROCAINAMIDE HYDROCHLORIDE 100 MG/ML
PROCAINAMIDE HYDROCHLORIDE 750 MG
PROCAINAMIDE HYDROCHLORIDE 1000 MG
PROCAINAMIDE HYDROCHLORIDE 500 MG/ML

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