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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
D D D- D0 D1 D2 D5 D7 D8 D9 DA DB DC DD DE DF DG DH DI DJ DK DL DM DN DO DP DR DS DT DU DV DW DX DY
DE DEA DEB DEC DED DEE DEF DEG DEH DEI DEJ DEK DEL DEM DEN DEO DEP DEQ DER DES DET DEU DEV DEX DEZ

Desmoplakin III

[Plakoglobin (gamma-Catenin) is a major soluble and membrane-associated cytoplasmic protein common to desmosomes and intermediate junctions. It associates with the cytoplasmic region of Desmoglein I and mediates the connection of cadherins to actin filaments and to other transmembrane and peripheral cytoplasmic proteins in epithelial adherens junctions. The cadherin-catenin complex interacts with EGFR; beta-Catenin and Plakoglobin are tyrosine phosphorylated by activated EGFR. APC binds to and regulates beta- and gamma-Catenin. Homologues of Drosophila armadillo, beta-Catenin and gamma-Catenin have analogous structures and functions in cell adhesion and the WNT signaling pathway. Several mutations of gamma-Catenin have transforming activity dependent on TCF/LEF and c-MYC function. Beta- and gamma-Catenin may have distinct roles in WNT signaling via differential effects on downstream target genes. (from OMIM 173325 and NCI) ( NCI )]
UMLS (NCI) C0137209
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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