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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
D D D- D0 D1 D2 D5 D7 D8 D9 DA DB DC DD DE DF DG DH DI DJ DK DL DM DN DO DP DR DS DT DU DV DW DX DY
DI DIA DIB DIC DID DIE DIF DIG DIH DII DIK DIL DIM DIN DIO DIP DIQ DIR DIS DIT DIU DIV DIZ

Diffimicin

[A member of the narrow-spectrum, 18-membered macrolide antibiotics (tiacumicins) isolated from cultures of Dactylosporangium aurantiacum subsp. hamdenensis and Actinoplanes deccanensis with potential antibacterial activity. Although the exact mechanism of action through which tiacumicin B exerts its effect has yet to be fully elucidated, this antibiotic may act by binding to and inhibiting bacterial DNA-dependent RNA polymerase, thereby inhibiting the initiation of bacterial RNA synthesis. After oral administration, tiacumicin B is not absorbed and exerts its effect locally in the intestines. In addition, this agent appears to be active against pathogenic gram-positive bacteria, such as clostridia, enterococci and staphylococci, but is not active against other intestinal bacteria, thereby allowing the normal gut flora to survive and exert its protective effect. ( NCI )]
UMLS (NCI) C0145907
 
Carbohydrate

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